Principal Scientist Research Computational Biology (ARIA)

Company: Amgen
Location: Washington
Posted on: February 12, 2026

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist Research Computational Biology (ARIA) What you will do Lets do this. The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline. In this role you will apply your expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets in a dynamic cross-functional research environment. Your scientific and technical leadership will help shape computational biology strategy across multiple discovery programs, influencing target selection, biomarker strategy, and translational hypotheses. Focus areas include: Driving extraction of biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses. Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities. Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships. Shaping roadmap priorities with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a computational biologist with these qualifications. Basic Qualifications: Doctorate in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable] and 2 years of computational biology experience Or Masters degree and 5 years of computational biology experience Or Bachelors degree and 7 years of computational biology experience Preferred Qualifications: Strong research background in cardiometabolic disease and/or immunology, including mechanistic characterization of disease biology using multi-modal single-cell data. Proven track record of driving programs or platforms that have materially impacted discovery or early development decisions. Experience mentoring scientists and setting standards for computational best practices within a team Ability to integrate portfolio-level business context into research strategy Strong programming skills (Python, R, Linux/Unix), familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git). Track record of designing and implementing creative and holistic computational strategies to address challenging research questions. Demonstrated expertise in the analysis and interpretation of single cell omics data. Excellent presentation and communication skills to convey complex findings to diverse audiences. Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs to further research goals. Familiarity with public data resources (e.g. DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M) frequently used to augment analyses of internally generated data. Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g. RShiny, Streamlit), workflow management systems (e.g Nextflow), and agentic frameworks. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen anticipates accepting applications until 2/16/26; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Keywords: Amgen, Bel Air North , Principal Scientist Research Computational Biology (ARIA), Science, Research & Development , Washington, Maryland